Amidite RSM Impurity Control and Impact on Oligonucleotide API Quality

William Fang, Vice President of Oligonucleotide and Peptide Development at WuXi TIDES

Amidite RSM Impurity Control and Impact on Oligonucleotide API Quality

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William Fang is the Vice President and Head of the Oligo/Peptide Development at WuXi TIDES, an integral part of WuXi AppTec. He has held various roles for over ten years with WuXi AppTec and has extensive experience in peptide R&D and manufacturing. Previously he worked at Zhejiang Runxin Pharmtech and Polypeptide labs. William received his bachelor’s degree from Beijing Medical University, his Master’s degree from Creighton University, and his MBA at UCLA.

Effective amidite impurities control is critical in solid-phase oligonucleotide synthesis, directly impacting the quality of oligonucleotide API. This presentation will explore the sources and control strategies for various impurities in oligonucleotide API, emphasizing the critical role of amidite impurity control in maintaining API quality. Additionally, the talk will touch upon strategies to establish a resilient supply chain for oligonucleotides, including robust supplies of high-quality amidite.