Significant investments have been made in upstream technologies and processes, with the goal of increasing upstream yields – including efforts to improve raw material characterisation, add single-use systems, perfusion systems and more precisely controlled bioreactors.
On the downstream side, improvements in throughput have not kept a similar pace to those for upstream, leading to potential bottlenecks in the end-to-end process.
Finding efficiencies across downstream processing steps and cost-effectively aligning the productivity of downstream production with upstream yields requires complex analysis and optimisation.
This presentation elaborates on the key aspects of downstream processing, looking at different areas where improvements by new techniques and new technologies could be made, from current process chromatography technologies, new powder and liquid handling strategies to raw material data analysis.
The presentation will be immediately followed by a live panel discussion with additional Avantor subject matter experts on the topic of optimizing downstream processes.
Christiane Schwittay, Director, Strategic
Marketing Biopharma Production, Avantor
