How to Use Display Technologies to Discover Therapeutic Proteins Against Challenging Targets

George Wang, PhD, Vice President of Antibody Discovery at WuXi Biologics

How to Use Display Technologies to Discover Therapeutic Proteins Against Challenging Targets

The speaker will share the data generated from the construction of large VHH, scFv and Fab libraries. These libraries are typically used to generate antibodies against challenging targets such as GPCR. Several case studies will be shown that demonstrate that phage/yeast-display can be used to improve affinity, manipulate pH dependency, and improve the developability of antibodies, TCRs and other proteins.

Speaker

George Wang, PhD
Vice President of Antibody Discovery at WuXi Biologics

Dr. George Wang, Vice President of Biologics Innovation & Discovery at WuXi Biologics, currently is responsible for Discovery and Preclinical Service, covering contract service of therapeutic proteins from concept to IND filing. Dr. Wang played various leadership roles since he joined WuXi Biologics in 2014, including managing material generation for over 300 discovery projects, initiating domain antibody group, and establishing several bispecific antibody platforms. He innovated the proprietary WuXiBody® bispecific antibody platform which has been licensed to 12 clients with over $500 million deal value.